Genetic testing before IVF. Is it a castle built on sand?

Genetic Testing Before IVF

Are you considering or currently on the IVF journey? Here's some information that might help with your decision-making process.

In the past two decades, there has been a significant rise in IVF clinics worldwide offering costly testing of embryos to make sure they have the right number of chromosomes.

Genetic testing for aneuploidy (PGT-A) has become a routine add-on for in vitro fertilization (IVF) to determine whether human embryos are to be clinically utilized or disposed of.

The idea is that this process improves the chances of having a baby by transferring only chromosomally normal embryos.

A recently published study shows pre-implantation genetic testing for aneuploidy (PGT-A), as the test is called, does not increase the odds of having a baby, at least not in women under the age of 38.

"PGT-A was never clinically validated to accurately classify human embryos as chromosomally normal, mosaic, or aneuploid nor certified by a regulatory body, or an authoritative professional organisation".

Because of a high false-positive rate, PGT-A actually reduces live IVF birth chances for many patients.

Furthermore, in recent studies the PGT-A hypothesis was demonstrated to be mistaken for biological, mathematical and technical reasons. PGT-A, therefore, should clinically only be offered within experimental study framework.

For the details click on the images below:

Live Birth with or without Preimplantation Genetic Testing for Aneuploidy:

Testing embryos before IVF doesn’t increase the chance of a baby